Senior Director, Toxicology
Alnylam was founded in 2002 on a revolutionary vision and bold mission which remain firmly in place today. We are leading the translation of RNAi as a new class of medicines with a core focus on RNAi therapeutics toward genetically defined targets for the treatment of serious, life-threatening diseases with limited treatment options for patients and their caregivers. In January 2015, we announced our Alnylam 2020 guidance that reflects our expected transition from a late-stage clinical development company to a multi-product commercial-stage company with a sustainable development pipeline. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work in 2015 and 2016.
Senior Director/Director, Toxicology
Summary of Key Responsibilities
Required:
Leadership excellence in people management and oversight of complex toxicological issues
Proven/demonstrated organizational strategy related to building strong scientific organizations
Expected:
Interface effectively and knowledgeably with related disciplines (be highly conversant) including pathology, DMPK, biology, clinical, regulatory, pharmacology.
Capable of highly effective interactions with Regulatory bodies in the process of product defense and support of filings and approval.
Design and execute robust strategically sound nonclinical development programs and studies required to support drug candidate advancement and regulatory filings.
Lead and manage non clinical studies/programs (conducted both internally and through CRO partners) either directly or through subordinates across a number of programs.
Ability to critically evaluate written scientific and regulatory documents for overall quality, clarity of presentation, and acceptability of scientific interpretation.
Collaborate on design of investigative toxicology studies in support of development compounds or platform technology assessments.
Interact cross functionally within the Drug Safety and Metabolism group, with project teams, as well as across other drug development expertise areas.
Present key findings and influence thinking of program teams, R&D leadership, and regulatory authorities.
Manage and mentor less senior toxicologists and scientists and guide the establishment of organizational expertise around the discipline of pharmaceutical toxicology and safety.
Responsible for hiring, professional development, and guidance of direct reports.
Qualifications
PhD in Toxicology, Pathology, or related discipline
10-15 years or more experience in the Pharmaceutical Industry with proven abilities and achievements within the Discovery Toxicology/Investigative/Regulatory Toxicology arena for predictive safety assessments.
Ability to interpret and integrate complex data sets across multiple disciplines including pharmacology, DMPK, toxicology and pathology assessing the clinical relevance and impact.
Proven ability to creatively seek resolutions to issues of predictive toxicology.
Strong problem solver who is highly organized with the ability to thrive and to lead in an environment with rapidly changing priorities.
Strong interpersonal skills with an ability to develop solid, long term relationships and the ability to influence others, and adept at working across multiple cross-functional areas.
Ability to navigate and be successful in a fast-paced, highly-networked and program team driven environment
Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.
. Apply now!Estimated Salary: $20 to $28 per hour based on qualifications.
Senior Director/Director, Toxicology
Summary of Key Responsibilities
Required:
Leadership excellence in people management and oversight of complex toxicological issues
Proven/demonstrated organizational strategy related to building strong scientific organizations
Expected:
Interface effectively and knowledgeably with related disciplines (be highly conversant) including pathology, DMPK, biology, clinical, regulatory, pharmacology.
Capable of highly effective interactions with Regulatory bodies in the process of product defense and support of filings and approval.
Design and execute robust strategically sound nonclinical development programs and studies required to support drug candidate advancement and regulatory filings.
Lead and manage non clinical studies/programs (conducted both internally and through CRO partners) either directly or through subordinates across a number of programs.
Ability to critically evaluate written scientific and regulatory documents for overall quality, clarity of presentation, and acceptability of scientific interpretation.
Collaborate on design of investigative toxicology studies in support of development compounds or platform technology assessments.
Interact cross functionally within the Drug Safety and Metabolism group, with project teams, as well as across other drug development expertise areas.
Present key findings and influence thinking of program teams, R&D leadership, and regulatory authorities.
Manage and mentor less senior toxicologists and scientists and guide the establishment of organizational expertise around the discipline of pharmaceutical toxicology and safety.
Responsible for hiring, professional development, and guidance of direct reports.
Qualifications
PhD in Toxicology, Pathology, or related discipline
10-15 years or more experience in the Pharmaceutical Industry with proven abilities and achievements within the Discovery Toxicology/Investigative/Regulatory Toxicology arena for predictive safety assessments.
Ability to interpret and integrate complex data sets across multiple disciplines including pharmacology, DMPK, toxicology and pathology assessing the clinical relevance and impact.
Proven ability to creatively seek resolutions to issues of predictive toxicology.
Strong problem solver who is highly organized with the ability to thrive and to lead in an environment with rapidly changing priorities.
Strong interpersonal skills with an ability to develop solid, long term relationships and the ability to influence others, and adept at working across multiple cross-functional areas.
Ability to navigate and be successful in a fast-paced, highly-networked and program team driven environment
Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.
. Apply now!Estimated Salary: $20 to $28 per hour based on qualifications.
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